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IOCB Tony Holý Lecture: Morten Peter Meldal – The INAIC reaction
Event by: IOCB Prague - Institute of Organic Chemistry and Biochemistry, Kampus Dejvice
Location: Flemingovo nám. 542/2, Flemingovo náměstí 2, Praha 6
Discussions and lectures
About event
🗣️ We are looking forward to hosting Prof. Morten Peter Meldal (University of Copenhagen, Denmark) with an invited lecture "The INAIC reaction: An intramolecular click reaction".
"The CuAAC click reaction discovered in 2001 will be described, with mechanistic discussions and applications. The criteria for a click reaction will be outlined, and our INAIC click reaction will be presented. This reaction was discovered by NMR investigations of peptide aldehydes, which showed entropy-driven quantitative and highly selective reaction with backbone or sidechain amides in the peptide, to form reactive N-acyl iminium ions. These react with C, O, N or S nucleophiles in a tandem intramolecular reaction to form multiple heterocycles in a stereo- and enantioselective manner. A range of 3D-ligands for GPCRs was produced and assayed in a special gene eGFP reporter assay. Cells were attached to beads and mixed with a combinatorial split/mix library of putative agonist ligands. Active ligands were identified. A small library of clicked, macrocyclic peptides was produced and screened for MC4R activation."
Learn more at ► https://www.uochb.cz/en/event-calendar/332/tony-holy-lecture-morten-peter-meldal ⤵
Find the next #IOCBInvitedLecture ► uochb.cz/en/iocb-invited-lectures-2025 ⤵
"The CuAAC click reaction discovered in 2001 will be described, with mechanistic discussions and applications. The criteria for a click reaction will be outlined, and our INAIC click reaction will be presented. This reaction was discovered by NMR investigations of peptide aldehydes, which showed entropy-driven quantitative and highly selective reaction with backbone or sidechain amides in the peptide, to form reactive N-acyl iminium ions. These react with C, O, N or S nucleophiles in a tandem intramolecular reaction to form multiple heterocycles in a stereo- and enantioselective manner. A range of 3D-ligands for GPCRs was produced and assayed in a special gene eGFP reporter assay. Cells were attached to beads and mixed with a combinatorial split/mix library of putative agonist ligands. Active ligands were identified. A small library of clicked, macrocyclic peptides was produced and screened for MC4R activation."
Learn more at ► https://www.uochb.cz/en/event-calendar/332/tony-holy-lecture-morten-peter-meldal ⤵
Find the next #IOCBInvitedLecture ► uochb.cz/en/iocb-invited-lectures-2025 ⤵